Keselamatan dari Honda Brio adalah sebagai berikut:
| Varian | Honda Brio Satya S | Honda Brio Satya E | Honda Brio Satya E CVT | Honda Brio RS | Honda Brio RS CVT |
| Peringkat Euro NCAP | |||||
| Peringkat ASEAN NCAP | |||||
| Jumlah airbag | |||||
| Airbag kursi penumpang / utama | |||||
| Airbag sisi depan / belakang | |||||
| Airbag lutut | |||||
| Pengingat sabuk pengaman | |||||
| Active emergency braking system | |||||
| Tire Pressure Monitoring System (TPMS) | N | N | N | N | N |
| Lane Departure Warning System (LDWS) | |||||
| Lane Keeping Assist System (LKAS) | |||||
| Collision avoidance system(CAS) | |||||
| Anti-lock Braking System (ABS) | |||||
| Electronic Brake-force Distribution (EBD) | Y | Y | Y | Y | Y |
| Sistem kontrol traksi | |||||
| Vehicle Stability Control (VSC) | |||||
| Child safety lock | Y | Y | Y | Y | Y |
| ISOFIX | |||||
| Security alert | |||||
| Immobilizer | Y | Y | Y | Y | Y |
