Hiburan & Komunikasi dari Mercedes-Benz E-Class adalah sebagai berikut:
| Varian | Mercedes-Benz E-Class E 200 Avantgarde Line | Mercedes-Benz E-Class E 300 SportStyle Avantgarde Line | Mercedes-Benz E-Class E 350 AMG Line | Mercedes-Benz E-Class E 300 Coupe AMG Line | Mercedes-Benz E-Class AMG E 43 4MATIC | Mercedes-Benz E-Class E300e AMG Line | Mercedes-Benz E-Class AMG E 63 S 4MATIC+ |
| Konfigurasi Layar Head unit | |||||||
| Ukuran Layar Head unit（inch) | |||||||
| Sistem Navigasi | Y | Y | Y | Y | |||
| Pengontrol Media Baris belakang | |||||||
| Bluetooth | Y | Y | Y | Y | Y | Y | Y |
| Integrasi Smartphone | |||||||
| Sistem perintah suara | Y | Y | Y | Y | N | ||
| Power Socket | Y | Y | Y | Y | Y | Y | Y |
| AUX | |||||||
| Pemutar CD/DVD | |||||||
| Merek Speaker | |||||||
| Jumlah speaker |
