Keselamatan dari Mercedes-Benz GLC-Class adalah sebagai berikut:
| Varian | Mercedes-Benz GLC-Class 200 Exclusive Line | Mercedes-Benz GLC-Class 200 AMG Line | Mercedes-Benz GLC-Class 300 Coupe 4MATIC AMG Line | Mercedes-Benz GLC-Class AMG 43 4MATIC Coupe |
| Peringkat Euro NCAP | ||||
| Peringkat ASEAN NCAP | ||||
| Jumlah airbag | ||||
| Airbag kursi penumpang / utama | ||||
| Airbag sisi depan / belakang | ||||
| Airbag lutut | ||||
| Pengingat sabuk pengaman | ||||
| Active emergency braking system | ||||
| Tire Pressure Monitoring System (TPMS) | Y | Y | ||
| Lane Departure Warning System (LDWS) | ||||
| Lane Keeping Assist System (LKAS) | ||||
| Collision avoidance system(CAS) | ||||
| Anti-lock Braking System (ABS) | ||||
| Electronic Brake-force Distribution (EBD) | Y | Y | Y | Y |
| Sistem kontrol traksi | ||||
| Vehicle Stability Control (VSC) | ||||
| Child safety lock | Y | Y | Y | Y |
| ISOFIX | ||||
| Security alert | ||||
| Immobilizer | Y | Y | Y | Y |
