Mesin dan Performa dari Kawasaki Ninja ZX-25R yaitu:
| Varian | Kawasaki Ninja ZX-25R ABS SE | Kawasaki Ninja ZX-25R Standard |
| Konfigurasi Katup | DOHC | DOHC |
| Kecepatan maksimum | ||
| Rasio Kompresi | 11.5:1 | 11.5:1 |
| Busi per silinder | ||
| Launch Control | ||
| RPM torsi maksimum | 14500 rpm | 14500 rpm |
| Jumlah silinder | 4 | 4 |
| Sistem pelumasan | Forced Lubrication, Wet Sump | Forced Lubrication, Wet Sump |
| RPM Tenaga Maksimum | 15500 rpm | 15500 rpm |
| Konsumsi Bahan Bakar | ||
| Sistem Pendinginan | ||
| Sistem pembakaran | B&C (TCBI EL. ADV. D.) | B&C (TCBI EL. ADV. D.) |
| Katup Per Silinder | 4 | 4 |
| Torsi Maksimal | 22.9 Nm | 22.9 Nm |
| Diameter x langkah | 50 mm x 31.8 mm | 50 mm x 31.8 mm |
| Jumlah langkah | 4-Stroke | 4-Stroke |
| Jenis Kopling | Wet, Multi-Plate, Manual | Wet, Multi-Plate, Manual |
| Pipa Knalpot | 4 Into 1 Exhaust | 4 Into 1 Exhaust |
| Tipe filter udara | ||
| Kontrol Emisi |
