Mesin dan Performa dari Honda CBR150R yaitu:
| Varian | Honda CBR150R MotoGP Edition | Honda CBR150R MotoGP Edition ABS | Honda CBR150R Racing Red | Honda CBR150R Racing Red ABS | Honda CBR150R STD | Honda CBR150R STD ABS |
| Konfigurasi Katup | DOHC | DOHC | DOHC | DOHC | DOHC | DOHC |
| Kecepatan maksimum | ||||||
| Rasio Kompresi | 11.3:1 | 11.3:1 | 11.3:1 | 11.3:1 | 11.3:1 | 11.3:1 |
| Busi per silinder | ||||||
| Launch Control | N | N | N | N | N | N |
| RPM torsi maksimum | 7000 rpm | 7000 rpm | 7000 rpm | 7000 rpm | 7000 rpm | 7000 rpm |
| Jumlah silinder | 1 | 1 | 1 | 1 | 1 | 1 |
| Sistem pelumasan | ||||||
| RPM Tenaga Maksimum | 9000 rpm | 9000 rpm | 9000 rpm | 9000 rpm | 9000 rpm | 9000 rpm |
| Konsumsi Bahan Bakar | ||||||
| Sistem Pendinginan | ||||||
| Sistem pembakaran | Full Transisterized | Full Transisterized | Full Transisterized | Full Transisterized | Full Transisterized | Full Transisterized |
| Katup Per Silinder | 4 | 4 | 4 | 4 | 4 | 4 |
| Torsi Maksimal | 14.4 Nm | 14.4 Nm | 14.4 Nm | 14.4 Nm | 14.4 Nm | 14.4 Nm |
| Diameter x langkah | 57.3 mm x 57.8 mm | 57.3 mm x 57.8 mm | 57.3 mm x 57.8 mm | 57.3 mm x 57.8 mm | 57.3 mm x 57.8 mm | 57.3 mm x 57.8 mm |
| Jumlah langkah | 4-Stroke | 4-Stroke | 4-Stroke | 4-Stroke | 4-Stroke | 4-Stroke |
| Jenis Kopling | Wet | Wet, Multi-Plate | Wet | Wet, Multi-Plate | Wet | Wet, Multi-Plate |
| Pipa Knalpot | Single Exhaust | Single Exhaust | Single Exhaust | Single Exhaust | Single Exhaust | Single Exhaust |
| Tipe filter udara | ||||||
| Kontrol Emisi | Euro 3 | Euro 3 | Euro 3 | Euro 3 | Euro 3 | Euro 3 |
