Mesin dan Performa dari Aprilia RSV4 yaitu:
| Varian | Aprilia RSV4 RF Standard | Aprilia RSV4 RR Race Pack |
| Konfigurasi Katup | DOHC | DOHC |
| Kecepatan maksimum | 300 kmph | 291 kmph |
| Rasio Kompresi | 13.5:1 | 13.5:1 |
| Busi per silinder | ||
| Launch Control | Y | Y |
| RPM torsi maksimum | 10500 rpm | 10500 rpm |
| Jumlah silinder | 4 | 4 |
| Sistem pelumasan | Wet Sump | Wet Sump |
| RPM Tenaga Maksimum | 13000 rpm | 13000 rpm |
| Konsumsi Bahan Bakar | ||
| Sistem Pendinginan | ||
| Sistem pembakaran | Elektronik | Elektronik |
| Katup Per Silinder | 4 | 4 |
| Torsi Maksimal | 115 Nm | 115 Nm |
| Diameter x langkah | 78 mm x 52.3 mm | 78 mm x 52.3 mm |
| Jumlah langkah | 4-Stroke | 4-Stroke |
| Jenis Kopling | ||
| Pipa Knalpot | Single Exhaust | Single Exhaust |
| Tipe filter udara | ||
| Kontrol Emisi |
