Mesin dan Performa dari MV Agusta F4 yaitu:
| Varian | MV Agusta F4 RC | MV Agusta F4 RR | MV Agusta F4 Standard |
| Konfigurasi Katup | DOHC | DOHC | DOHC |
| Kecepatan maksimum | 302 kmph | 298 kmph | 297 kmph |
| Rasio Kompresi | 13.4:1 | 13.4:1 | 13.4:1 |
| Busi per silinder | |||
| Launch Control | |||
| RPM torsi maksimum | 9300 rpm | 9600 rpm | 9600 rpm |
| Jumlah silinder | 4 | 4 | 4 |
| Sistem pelumasan | |||
| RPM Tenaga Maksimum | 13600 rpm | 13600 rpm | 13400 rpm |
| Konsumsi Bahan Bakar | |||
| Sistem Pendinginan | |||
| Sistem pembakaran | MVICS (Motor & Vehicle Integrated Control System) | MVICS (Motor & Vehicle Integrated Control System) | MVICS (Motor & Vehicle Integrated Control System) |
| Katup Per Silinder | 4 | 4 | 4 |
| Torsi Maksimal | 115 Nm | 111 Nm | 110.8 Nm |
| Diameter x langkah | 79 mm x 50.9 mm | 79 mm x 50.9 mm | 79 mm x 50.9 mm |
| Jumlah langkah | 4-Stroke | 4-Stroke | 4-Stroke |
| Jenis Kopling | Wet, Multi-Plate | Wet, Multi-Plate | Wet, Multi-Plate |
| Pipa Knalpot | Single Exhaust | Single Exhaust | Single Exhaust |
| Tipe filter udara | |||
| Kontrol Emisi | Euro 3 | Euro 3 | Euro 3 |
