Mesin dan Performa dari Kawasaki Ninja 250 yaitu:
| Varian | Kawasaki Ninja 250 ABS MDP SE | Kawasaki Ninja 250 ABS SE | Kawasaki Ninja 250 SE MDP |
| Konfigurasi Katup | DOHC | DOHC | DOHC |
| Kecepatan maksimum | 170 kmph | 170 kmph | 170 kmph |
| Rasio Kompresi | 11.6:1 | 11.6:1 | 11.6:1 |
| Busi per silinder | |||
| Launch Control | N | N | N |
| RPM torsi maksimum | 10000 rpm | 10000 rpm | 10000 rpm |
| Jumlah silinder | 2 | 2 | 2 |
| Sistem pelumasan | |||
| RPM Tenaga Maksimum | 12500 rpm | 12500 rpm | 12500 rpm |
| Konsumsi Bahan Bakar | |||
| Sistem Pendinginan | |||
| Sistem pembakaran | Digital | Digital | Digital |
| Katup Per Silinder | 4 | 4 | 4 |
| Torsi Maksimal | 23.5 Nm | 23.5 Nm | 23.5 Nm |
| Diameter x langkah | 62 mm x 41.2 mm | 62 mm x 41.2 mm | 62 mm x 41.2 mm |
| Jumlah langkah | 4-Stroke | 4-Stroke | 4-Stroke |
| Jenis Kopling | Wet Multi-Plate, Manual | Wet Multi-Plate, Manual | Wet Multi-Plate, Manual |
| Pipa Knalpot | Single Exhaust | Single Exhaust | Single Exhaust |
| Tipe filter udara | |||
| Kontrol Emisi |
