Dimensions dari Mercedes-Benz E-Class adalah sebagai berikut:
| Varian | Mercedes-Benz E-Class E 200 Avantgarde Line | Mercedes-Benz E-Class E 300 SportStyle Avantgarde Line | Mercedes-Benz E-Class E 350 AMG Line | Mercedes-Benz E-Class E 300 Coupe AMG Line | Mercedes-Benz E-Class AMG E 43 4MATIC | Mercedes-Benz E-Class E300e AMG Line | Mercedes-Benz E-Class AMG E 63 S 4MATIC+ |
| Panjang (mm) | 4923 | 4923 | 4940 | 4703 | 4923 | 4923 | 4879 |
| Lebar (mm) | 2065 | 2065 | 2065 | 1786 | 1852 | 1852 | 1854 |
| Tinggi (mm) | 1468 | 1468 | 1452 | 1397 | 1474 | 1468 | 1475 |
| Jarak sumbu roda (mm) | 2760 | 2939 | 2874 | ||||
| Berat bersih (kg) | 1695 | 1735 | 1750 | 1680 | 1940 | ||
| Ground clearance (mm) | |||||||
| Jumlah pintu(buah) | 4 | 4 | 4 | 2 | 4 | 4 | 4 |
| Jumlah tempat duduk(buah) | 5 | 5 | 5 | 5 | 5 | 5 | 5 |
| Tangki bahan bakar (Liter) | 66 | 66 | 66 | 66 | 66 | 66 | |
| Kapasitas bagasi (L) | 540 |
