Keselamatan dari Porsche Cayenne adalah sebagai berikut:
| Varian | Porsche Cayenne Diesel 245 hp Tiptronic | Porsche Cayenne S E-Hybrid Tiptronic | Porsche Cayenne S Tiptronic S | Porsche Cayenne S Tiptronic | Porsche Cayenne Turbo Tiptronic | Porsche Cayenne Turbo S Tiptronic | Porsche Cayenne GTS Tiptronic |
| Peringkat Euro NCAP | |||||||
| Peringkat ASEAN NCAP | |||||||
| Jumlah airbag | |||||||
| Airbag kursi penumpang / utama | |||||||
| Airbag sisi depan / belakang | |||||||
| Airbag lutut | |||||||
| Pengingat sabuk pengaman | |||||||
| Active emergency braking system | |||||||
| Tire Pressure Monitoring System (TPMS) | Y | Y | Y | Y | Y | Y | Y |
| Lane Departure Warning System (LDWS) | |||||||
| Lane Keeping Assist System (LKAS) | |||||||
| Collision avoidance system(CAS) | |||||||
| Anti-lock Braking System (ABS) | |||||||
| Electronic Brake-force Distribution (EBD) | Y | Y | Y | Y | Y | Y | Y |
| Sistem kontrol traksi | |||||||
| Vehicle Stability Control (VSC) | |||||||
| Child safety lock | Y | Y | Y | Y | Y | Y | Y |
| ISOFIX | |||||||
| Security alert | |||||||
| Immobilizer | Y | Y | Y | Y | Y | Y | Y |
