Keselamatan dari Hyundai Santa Fe adalah sebagai berikut:
| Varian | Hyundai Santa Fe 2.2L CRDi GLS | Hyundai Santa Fe 2.2L CRDi XG | Hyundai Santa Fe Grand | Hyundai Santa Fe 2.4L MPI GLS | Hyundai Santa Fe 2.4L MPI XG |
| Peringkat Euro NCAP | |||||
| Peringkat ASEAN NCAP | |||||
| Jumlah airbag | |||||
| Airbag kursi penumpang / utama | |||||
| Airbag sisi depan / belakang | |||||
| Airbag lutut | |||||
| Pengingat sabuk pengaman | |||||
| Active emergency braking system | |||||
| Tire Pressure Monitoring System (TPMS) | |||||
| Lane Departure Warning System (LDWS) | |||||
| Lane Keeping Assist System (LKAS) | |||||
| Collision avoidance system(CAS) | |||||
| Anti-lock Braking System (ABS) | |||||
| Electronic Brake-force Distribution (EBD) | Y | Y | Y | Y | Y |
| Sistem kontrol traksi | |||||
| Vehicle Stability Control (VSC) | |||||
| Child safety lock | Y | Y | Y | Y | Y |
| ISOFIX | |||||
| Security alert | |||||
| Immobilizer | Y | Y | Y | Y | Y |
