Kenyamanan dari Mercedes-Benz E-Class adalah sebagai berikut:
| Varian | Mercedes-Benz E-Class E 200 Avantgarde Line | Mercedes-Benz E-Class E 300 SportStyle Avantgarde Line | Mercedes-Benz E-Class E 350 AMG Line | Mercedes-Benz E-Class E 300 Coupe AMG Line | Mercedes-Benz E-Class AMG E 43 4MATIC | Mercedes-Benz E-Class E300e AMG Line | Mercedes-Benz E-Class AMG E 63 S 4MATIC+ |
| Sensor parkir depan | |||||||
| Sensor parkir belakang | |||||||
| Driving assistance image | Y | Y | Y | Y | Y | ||
| Cruise system | Y | Y | |||||
| Parkir otomatis | |||||||
| Start/Stop engine button | Y | Y | Y | Y | |||
| Hill Start Assist (HSA) | |||||||
| Hill Descent Control (HDC) | |||||||
| Pengatur Moda Berkendara | |||||||
| limited-slip differential (LSD) | |||||||
| Differential lock | |||||||
| Headlight height adjustment |
