Berikut adalah Mesin dan varian Mercedes-Benz E-Class:
| Varian | Mercedes-Benz E-Class E 200 Avantgarde Line | Mercedes-Benz E-Class E 300 SportStyle Avantgarde Line | Mercedes-Benz E-Class E 350 AMG Line | Mercedes-Benz E-Class E 300 Coupe AMG Line | Mercedes-Benz E-Class AMG E 43 4MATIC | Mercedes-Benz E-Class E300e AMG Line | Mercedes-Benz E-Class AMG E 63 S 4MATIC+ |
| Mesin | 2.0L Petrol Engine, In-Line 4 Cylinder 16 Valve | 2.0L Petrol Engine, In-Line 4 Cylinder 16 Valve | 2.0L Petrol Engine, In-Line 4 Cylinder 16 Valve | 2.0 L | 2.0 L | 2.0L Hybrid Engine, 4 Cylinder 16 Valve DOHC | 5461 cc |
