Mesin dan Performa dari Honda ADV 150 yaitu:
| Varian | Honda ADV 150 ABS | Honda ADV 150 CBS |
| Konfigurasi Katup | SOHC | SOHC |
| Kecepatan maksimum | 117 kmph | 117 kmph |
| Rasio Kompresi | 10.6:1 | 10.6:1 |
| Busi per silinder | 1 | 1 |
| Launch Control | N | N |
| RPM torsi maksimum | 6500 rpm | 6500 rpm |
| Jumlah silinder | 1 | 1 |
| Sistem pelumasan | Dry Sump | Dry Sump |
| RPM Tenaga Maksimum | 8500 rpm | 8500 rpm |
| Konsumsi Bahan Bakar | 50.7 kmpl | 50.7 kmpl |
| Sistem Pendinginan | ||
| Sistem pembakaran | Full Transisterized | Full Transisterized |
| Katup Per Silinder | 1 | 1 |
| Torsi Maksimal | 13.8 Nm | 13.8 Nm |
| Diameter x langkah | 57.3 mm x 57.9 mm | 57.3 mm x 57.9 mm |
| Jumlah langkah | 4-Stroke | 4-Stroke |
| Jenis Kopling | Automatic, Centrifugal, Dry Type | Automatic, Centrifugal, Dry Type |
| Pipa Knalpot | Single Exhaust | Single Exhaust |
| Tipe filter udara | ||
| Kontrol Emisi | Euro 3 | Euro 3 |
