Fitur Keselamatan dan Keamanan dari Honda CBR150R yaitu:
| Varian | Honda CBR150R MotoGP Edition | Honda CBR150R MotoGP Edition ABS | Honda CBR150R Racing Red | Honda CBR150R Racing Red ABS | Honda CBR150R STD | Honda CBR150R STD ABS |
| Fitur keselamatan | ||||||
| Penutup lubang kunci | N | N | N | N | N | N |
| ABS | N | Y | N | Y | N | Y |
| Immobilizer | N | N | N | N | N | N |
| Stability Control | ||||||
| Engine Check Warning | Y | Y | Y | Y | Y | Y |
| Alarm | N | N | N | N | N | N |
| Wheel lock depan/belakang | N | N | N | N | N | N |
| Indikator Standar Samping | N | N | N | N | N | N |
| Traction Control | N | N | N | N | N | N |
| Reflektor samping | N | N | N | N | N | N |
