Mesin dan Performa dari Honda CRF1100L Africa Twin yaitu:
| Varian | Honda CRF1100L Africa Twin DCT | Honda CRF1100L Africa Twin Manual |
| Konfigurasi Katup | SOHC | SOHC |
| Kecepatan maksimum | 217 kmph | 217 kmph |
| Rasio Kompresi | 10.1:1 | 10.1:1 |
| Busi per silinder | 1 | 1 |
| Launch Control | N | N |
| RPM torsi maksimum | 6000 rpm | 6000 rpm |
| Jumlah silinder | 2 | 2 |
| Sistem pelumasan | Wet Sump | Wet Sump |
| RPM Tenaga Maksimum | 7500 rpm | 7500 rpm |
| Konsumsi Bahan Bakar | 20.8 kmpl | 20.4 kmpl |
| Sistem Pendinginan | ||
| Sistem pembakaran | Full Transisterized | Full Transisterized |
| Katup Per Silinder | 4 | 4 |
| Torsi Maksimal | 105 Nm | 105 Nm |
| Diameter x langkah | 92 mm x 81.5 mm | 92 mm x 81.5 mm |
| Jumlah langkah | 4-Stroke | 4-Stroke |
| Jenis Kopling | Slipper Clutch, Wet Multi-Plate | Slipper Clutch, Wet Multi-Plate |
| Pipa Knalpot | Single Exhaust | Single Exhaust |
| Tipe filter udara | ||
| Kontrol Emisi | Euro 5 | Euro 5 |
