Keselamatan dari Mazda CX 5 adalah sebagai berikut:
| Varian | Mazda CX 5 Touring | Mazda CX 5 GT | Mazda CX 5 Elite |
| Peringkat Euro NCAP | 1 | 1 | 1 |
| Peringkat ASEAN NCAP | 1 | 1 | 1 |
| Jumlah airbag | 6 | 6 | 6 |
| Airbag kursi penumpang / utama | Y/Y | Y/Y | Y/Y |
| Airbag sisi depan / belakang | Y/Y | Y/Y | Y/Y |
| Airbag lutut | Y/Y | Y/Y | Y/Y |
| Pengingat sabuk pengaman | |||
| Active emergency braking system | Y | Y | Y |
| Tire Pressure Monitoring System (TPMS) | N | N | N |
| Lane Departure Warning System (LDWS) | |||
| Lane Keeping Assist System (LKAS) | Y | Y | Y |
| Collision avoidance system(CAS) | |||
| Anti-lock Braking System (ABS) | |||
| Electronic Brake-force Distribution (EBD) | Y | Y | Y |
| Sistem kontrol traksi | |||
| Vehicle Stability Control (VSC) | Y | Y | Y |
| Child safety lock | Y | Y | Y |
| ISOFIX | Y | Y | Y |
| Security alert | |||
| Immobilizer | Y | Y | Y |
