Keselamatan dari Honda Odyssey adalah sebagai berikut:
| Varian | Honda Odyssey 2.4L |
| Peringkat Euro NCAP | |
| Peringkat ASEAN NCAP | |
| Jumlah airbag | 6 |
| Airbag kursi penumpang / utama | Y/Y |
| Airbag sisi depan / belakang | Y/Y |
| Airbag lutut | Y/Y |
| Pengingat sabuk pengaman | Front Seats Only |
| Active emergency braking system | |
| Tire Pressure Monitoring System (TPMS) | N |
| Lane Departure Warning System (LDWS) | |
| Lane Keeping Assist System (LKAS) | |
| Collision avoidance system(CAS) | |
| Anti-lock Braking System (ABS) | |
| Electronic Brake-force Distribution (EBD) | Y |
| Sistem kontrol traksi | |
| Vehicle Stability Control (VSC) | |
| Child safety lock | Y |
| ISOFIX | Y |
| Security alert | |
| Immobilizer | Y |
