Keselamatan dari BMW M5 adalah sebagai berikut:
| Varian | BMW M5 4.4 L |
| Peringkat Euro NCAP | |
| Peringkat ASEAN NCAP | |
| Jumlah airbag | |
| Airbag kursi penumpang / utama | |
| Airbag sisi depan / belakang | |
| Airbag lutut | |
| Pengingat sabuk pengaman | |
| Active emergency braking system | |
| Tire Pressure Monitoring System (TPMS) | Y |
| Lane Departure Warning System (LDWS) | |
| Lane Keeping Assist System (LKAS) | |
| Collision avoidance system(CAS) | |
| Anti-lock Braking System (ABS) | |
| Electronic Brake-force Distribution (EBD) | |
| Sistem kontrol traksi | |
| Vehicle Stability Control (VSC) | |
| Child safety lock | Y |
| ISOFIX | |
| Security alert | |
| Immobilizer | Y |
