Keselamatan dari Toyota Avanza adalah sebagai berikut:
| Varian | Toyota Avanza 1.3E MT | Toyota Avanza 1.3E AT | Toyota Avanza 1.3G MT | Toyota Avanza 1.3G AT | Toyota Avanza 1.5G MT |
| Peringkat Euro NCAP | 4 | ||||
| Peringkat ASEAN NCAP | 4 | ||||
| Jumlah airbag | 6 | ||||
| Airbag kursi penumpang / utama | Y/Y | ||||
| Airbag sisi depan / belakang | Y/N | ||||
| Airbag lutut | N/N | ||||
| Pengingat sabuk pengaman | Ya | ||||
| Active emergency braking system | Y | ||||
| Tire Pressure Monitoring System (TPMS) | Y | ||||
| Lane Departure Warning System (LDWS) | N | ||||
| Lane Keeping Assist System (LKAS) | N | ||||
| Collision avoidance system(CAS) | N | ||||
| Anti-lock Braking System (ABS) | Y | ||||
| Electronic Brake-force Distribution (EBD) | Y | ||||
| Sistem kontrol traksi | N | ||||
| Vehicle Stability Control (VSC) | Y | ||||
| Child safety lock | Y | Y | Y | Y | Y |
| ISOFIX | Y | ||||
| Security alert | Y | ||||
| Immobilizer | Y | Y | Y | Y | Y |
